GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs1577917 | 1 | rs12215037 | chr6:86727631 | SNHG5 | chr6:86386726-86388451:- | -0.6 | -7.24 | 1.15E-10 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs12215903 | chr6:86675028 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.7 | 1.49E-9 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs12216203 | chr6:86675301 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs1577917 | 1 | rs12216328 | chr6:86703418 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -6.89 | 5.95E-10 | Response to antipsychotic treatment |
| THYM | cis | rs2463822 | 1 | rs12279819 | chr11:62137245 | ASRGL1 | chr11:62104774-62160885:+ | -0.55 | -5.39 | 5.18E-7 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs494003 | 1 | rs12287832 | chr11:65553492 | SNX32 | chr11:65601410-65621170:+ | 0.56 | 5.74 | 1.12E-7 | Systemic lupus erythematosus |
| THYM | cis | rs7969151 | 1 | rs12309485 | chr12:54162461 | COPZ1 | chr12:54718911-54745633:+ | -0.29 | -4.68 | 9.47E-6 | Tanning |
| THYM | cis | rs7223966 | 1 | rs12325866 | chr17:61755974 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.41 | 2.72E-5 | Body mass index |
| THYM | cis | rs7072122 | 1 | rs12359952 | chr10:45032962 | ZNF22 | chr10:45496273-45500776:+ | 0.47 | 4.63 | 1.16E-5 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs6540731 | 1 | rs12402397 | chr1:212395944 | NEK2 | chr1:211836115-211848967:- | -0.17 | -4.33 | 3.71E-5 | Intelligence (childhood) |
| THYM | cis | rs2275426 | 1 | rs12405451 | chr1:46384326 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs12409773 | chr1:46358831 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -5.85 | 7.1E-8 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs12410071 | chr1:46358886 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -5.84 | 7.39E-8 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs12411269 | chr1:46271052 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -5.85 | 6.8E-8 | Body mass index |
| THYM | cis | rs9527 | 1 | rs12416687 | chr10:104629011 | AS3MT | chr10:104613967-104661653:+ | -0.4 | -4.38 | 3.11E-5 | Arsenic metabolism |